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the Fujian Medical University High-level Talent Research Startup Funding Project (XRCZX2020010) to Daoshan Zheng, as well as the Natural Science Foundation of Fujian Province (2023J01829) to Zeshou Gao

[52] in a randomized, double-blind, placebo-controlled clinical trial demonstrated that acute hyperglycemia significantly impaired endothelium-dependent vasodilation in healthy subjects, whereas treatment with the RBX effectively preserved vascular responses, thereby preventing hyperglycemia-induced endothelial dysfunction

Sequential therapy is well established in oncogene-driven cancers, particularly EGFR-mutant nonsmall cell lung cancer, where first or second-generation EGFR tyrosine kinase inhibitors are followed by Osimertinib upon emergence of T790M-mediated resistance (181183)