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1 Introduction Lifetime history of schizophrenia spectrum disorders, including schizophrenia and schizoaffective and schizophreniform disorders, within the US is estimated at 1.8% ( A systematic review and meta-analysis examining the global prevalence of metabolic syndrome in patients with schizophrenia found a pooled prevalence of 41.3%, with significant variability across regions, ranging from 79.1% in France to 18.03% in China ( Metabolic syndrome and antipsychotic-induced weight gain negatively impact quality of life and are common reasons for medication non-adherence and premature discontinuation, creating barriers to symptom remission among people with schizophrenia ( People with schizophrenia and comorbid metabolic syndrome have poorer cognitive performance, possibly resulting in worse symptom remission ( Immune dysregulation and chronic inflammation have been hypothesized as potential risk factors for both metabolic syndrome and the development and worsening of symptoms in individuals with schizophrenia

However, there are still aspects concerning NR as a biomarker for endocrine disruption that remains to be clarified

Conclusion Each treatment option for undereye dark circles comes with its own set of risks and potential side effects