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EV markers [Cluster of Differentiation 9 (CD9), Heat-shock protein90 (HSP90), Tumor susceptibility gene 101 (TSG-101)] were utilized as positive controls in the western blot analyses

The members of the caspase protein family (a key protein in apoptosis) are activated, resulting in a protease cascade amplification reaction process in which apoptotic signals are irreversibly amplified [12, 13]

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They lack control groups, they are subject to the placebo effect, and they don't account for other lifestyle changes a person might have made simultaneously