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36,37 Zonula occludens (ZO), including ZO-1 and its homologs ZO-2 and ZO-3, is a group of PDZ-related scaffolding proteins that belong to the superfamily of membrane-associated guanylate kinase-like proteins, possessing sites of three tandem PDZ domains at the N-terminus 38,39 (Figure 1)

To potentially move them into Category 1 or final Bulks List status, the most effective approach is to present a persuasive case for their clinical efficacy and safety to the Pharmacy Compounding Advisory Committee (PCAC) and submit it to the FDA

Amongst these compounds, 5-methyl-THF and 5,10-methyleneTHF play key roles insomuch as they orientate folate metabolism towards specific metabolic pathways (Figure 2)

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