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As antipsychotic discontinuation cannot occur in treatment periods without antipsychotic use, the outcomes of discontinuation and treatment failure were only analyzed during treatment periods with antipsychotic use

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Immune-based approaches Immune-based therapeutic strategies have been suggested for some patients with BD and MDD, although due to the biological and clinical heterogeneity of these complex disorders, this type of therapy could be considered as a part of personalized approach, beneficiating approximately one in three patients, according to previous studies [333]