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Abstract As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage

Mitochondrial mass per cell was subsequently determined by quantification of mean fluorescence intensity (MFI) green using a FACS Canto II flow cytometer (BD Biosciences, Franklin Lakes, NJ, USA)

The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference