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RESULTS Liver lesions and biochemistry assessment In controls, the grading system used to microscopically measure the extent of liver damage (the same for steatosis, necrosis, and congestion) showed no lesion presentation at the earliest point of 25 minutes after paracetamol ( Table 1 ), but liver enzymes and ammonium serum values were already increased ( Table 2 )

Then, we applied BPC 157 (dissolved in saline, 10.0 g, 10.0 ng, 10 pg/kg b.w.) or saline (5.0 ml/kg) intraperitoneally or intragastrically as follows: (i) prophylactically, immediately after or (ii) therapeutically, after 3 hours elapsed