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Raphael AP, Crichton ML, Falconer RJ, Meliga S, Chen X, Fernando GJP, Huang H, Kendall MAF

Most negative side effects are temporary

Dass das gleiche Medikament bei Menschen mit der gleichen Krankheit unterschiedlich wirken kann, ist seit langem bekannt

Notably, by solving Cryo-electron microscope (cryo-EM) structures of EP3-Gi, EP4-Gs, and EP4-Gi in complex with endogenous PGE2 or 2 synthetic agonists and comparing with PGE2-EP2-Gs structures, previous studies showed that unique primary sequences of prostaglandin E2 receptor (EP) receptors and distinct conformational states of the EP4 ligand pocket govern the Gs/Gi transducer coupling selectivity through different structural propagation paths, especially via TM6 and TM7, to generate selective cytoplasmic structural features