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iScience 26 , 107868 (2023)

In mouse models of PCOS, abnormal bile acid profiles are closely associated with the pathophysiology of the disease (Wang et al., 2026)

HHEX is crucial for maintaining the identity of the innermost adrenocortical cell subpopulation and promoting Abcb1b expression in both sexes The lower expression of Hhex in females compared to males after puberty and the lack of evident LD depletion in female Sf1-Cre high Hhex KO mice led us to question whether HHEX contributes to transcriptional programs in the female mouse adrenal cortex