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In both ESS mouse models and patients with pSS, tissue-specific CD8 + CD103 + CD69 + TRM was identified as being involved in sialadenitis, with a significant increase in IFN- production, in which CD69 and CD103 are the tissue residence markers (95)

Furthermore, as persulfides have a low pKa (~4.3) they are largely in the thiolate form in vivo, and due to the -effect of the non-terminal S atom are better nucleophiles than thiols 29

Jonasch E, Matin SF, Pagliaro LC, Wood CG, Tannir NM

Nat Struct Mol Biol 27:323332 Matsuo Y, Uchihashi T, Inada T (2023) Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex