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Interestingly, the categories enriched in the upregulated clusters are related to phagosome maturation, RNA and translation, but importantly multiple metabolism pathways including citric acid cycle, cholesterol metabolism, pentose phosphate pathway, electron transport chain, and glutathione metabolism

identified ZDHHC7 as the principal FAS palmitoyltransferase and demonstrated that palmitoylation mediated by ZDHHC7 protects FAS from lysosomal degradation (Figure 3-2), thereby modulating its expression [90]

Short answer: cycling is the reasonable approach, but not for the dramatic reasons people usually give

& Boeke, J