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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Tsao CW, Liao YR, Chang TC, Liew YF, Liu CY

The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions