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(Reference ODoherty, Freedman and Hollenbeck62) These findings highlight the impact of not only excess weight, as assessed through BMI, but also body fat distribution on GERD (Reference Krner, Corts and Lukens59)

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Importantly, most data correlating oxidative stress markers with ALS progression has been obtained using mutSOD1 animal models, in which the mechanisms behind oxidative stress are easy to devise but which are a surrogate for only a small proportion of all ALS patients