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Selenium supplementation for patients with Graves' hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial

This study demonstrates that MITOL-mediated K63-linked polyubiquitination at K68 of HMOX2 plays a crucial role in maintaining mitochondrial iron homeostasis

To achieve this, a group of 64 young and aged rats were allocated into groups, all of which would receive either a low or high dose of caffeine or paraxanthine, respectively

If blood loss continues long enough that body iron stores are depleted and absorption of dietary iron is inadequate to meet the demand created by increased red blood cell production, then iron becomes a limiting factor and effective erythropoiesis is decreased