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If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability

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Future Directions: To allow a better understanding of the complications associated with anemia in CVD, basic and translational science studies should be focused on identifying the role of noncanonical functions of RBCs in the cardiovascular system and on defining intrinsic and/or systemic dysfunction of RBCs in anemia and its relationship to CVD both in animal models and clinical settings