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In terms of mechanism, BCL2L1 binds to and suppresses PGAM5, a phosphatase located in the mitochondria, thereby preventing the dephosphorylation of FUNDC1 at Ser-13

Treatment of poor-prognosis newly-diagnosed (ND) AML or MDS with G-CSF prior to, during, and following fludarabine, and ARA-C (Flag)

Pharmaceutics 15:2 Manuel M, Tan KB, Kozic Z, Molinek M, Marcos TS, Razak MFA, Dobolyi D, Dobie R, Henderson BEP, Henderson NC, Chan WK, Daw MI, Mason JO, Price DJ (2022) Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals