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The receptors then migrate to one side of the endosome, whereas the LDLs stay free within the lumen of the vesicle

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Incubation of Fischer-344 rat nasal mucosal homogenate with acrolein resulted in a concentration-dependent increase in DNA-protein cross-linking, which was not observed following inhalation exposure of rats to acrolein at a concentration of 4.6 mg/m 3 for 6 h (Lam et al., 1985)