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In contrast, D-lactate has been observed to promote histone deacetylase (HDAC) protein gene expression, potentially serving as a crucial transcriptional regulator (132, 133)

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The healthier metabolic state was defined by higher glucose metabolism substrate levels and corresponded to higher levels of ketogenic AAs/BCAA metabolite derivatives (tyrosine, threonine, valine, 4-methyl-2-oxovaleric acid and propionylcarnitine), ketone bodies (3-hydroxybutyrate and 2-hydroxybutyrate), and butyrylcarnitine (a metabolite involved in fatty acid metabolism

However, certain amounts of ROS can be advantageous because they trigger the antioxidant defense system and shield cells