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The regulatory asymmetry between topical and injectable in the 503A list reflects, in part, that asymmetry in the evidence

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We demonstrate that IPA activates peroxisome proliferator-activated receptor alpha (PPAR) through specific ligand-binding domain interactions (Tyr314/Ile317), driving 3-hydroxy-3-methylglutaryl-CoA synthetase 2 (HMGCS2)-mediated ketogenesis to elevate -hydroxybutyrate (BHB) production