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Description

Neurotrauma 39 , 211226 (2022)

18 In brief, confluent cells were labeled with 14 C proline and (pro)collagen proteins were separated on sodium dodecyl sulfate-polyacrylamide gels

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We used CCW16, an RNF4-binding moiety [39], as a starting point for a focused small-molecule screen and identified an RNF4 binder with higher affinity (R4B), which served as a building block for developing more potent R4VPs