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Proteomic analyses of the oleaginous and carotenogenic yeast Rhodotorula diobovata across growth phases under nitrogen- and oxygen-limited conditions

The evidence, pieced together from various levels of biological complexity, paints a concerning yet coherent picture

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Cu+ binds to the fatty acylated pyruvate dehydrogenase complex, inducing abnormal oligomerization and inactivation of the enzyme, which prevents pyruvate conversion to acetyl-CoA and disrupts metabolic flow via the tricarboxylic acid cycle (173,183)