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2013 Nov 1;13(23):1-45

Some evidence: A randomized controlled study with 250 mg/day (reduced or oxidised form) over 12 weeks found that melanin index and UV-spots tended to be lower vs placebo

Concurrent use with other anti-inflammatory drugs or protein-bound drugs including cardiac, anticonvulsant and behavioral medications has not been studied

However, at least at the cellular level, direct evidence is needed for the relationship between the action of the studied active compounds and metallothioneins, the dissociation of Zn(II) ions, and their impact on specific signaling pathways