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While sharing some common modulating features, dual agonists (peptide 19 and LY3298176) and a triple agonist displayed differentiated signaling profiles as well as negative impact on the heteromerization that may help interpret their superior clinical efficacies

The generated tubuloids showed active transepithelial transport function and were used to model several diseases, including BK virus, Wilms tumor, and cystic fibrosis, showing the great potential of this culture system for disease modeling and the possibility to use it for drug screening (Schutgens et al

In this model, combination of anti-VEGF and anti-Gr1 reduces tumor growth while monotherapies are weakly efficient [62]

This signalling may disrupt cancer immune surveillance, promoting immune evasion and resistance to immunotherapies, including immune checkpoint blockers