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Since it has been shown that deficiency affects the expression of different genes in the liver, including NO-like actions that raise cGMP through elevated guanylate cyclase, biotin exerts a secondary role in controlling gene expression (147)

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6.2 Free radical cause nitric oxide The rate of whole body NO synthesis was increased in the end stage renal disease (ESRD) patients [108]

10.1080/15384047.2022.2094666 195 LiQ.HuW.HuangQ.YangJ.LiB.MaK.et al (2023a)