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For example, complex I inhibition by rotenone produces matrix ROS and inhibits ROS from reverse electron transfer, while complex III inhibition with antimycin A generates ROS in the inter-membrane space (IMS) 1,12,55,56,57 (Fig

The resulting stabilization of NRF2 facilitates its translocation to the nucleus, localization to the antioxidant response element (ARE), and transcription of cytoprotectant genes (23, 24) (Supplementary Fig

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Elisa Naomi Gorton, junior, Deans List, College of Education and Human Sciences, child, youth and family studies