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Description

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

However, this presents major problems

Finerenone, a novel non-steroidal selective MR antagonist (MRA), demonstrates fewer adverse effects on serum potassium levels and renal function compared to steroidal MRAs which have been approved by FDA for treatment of DKD (208)