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Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

However, the selection of appropriate model structures is often based on a trial-and-error approach (Richelle & Bogaerts, 2015)

Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6

MI involves mentally rehearsing movements without physical execution, and its neural substrates exhibit substantial overlap with the motor execution network (Bai et al., 2020)