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Sleep disturbances develop in up to 90% of PD individuals, significantly impacting on their quality of life [15, 17, 118, 196, 264], caregivers burden [25, 202, 220, 266] and disease progression, especially in case of RBD [157, 176]

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This is typically the dose tier where researchers begin to notice significant appetite suppression and where tirzepatide appetite effects become most pronounced