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As predicted by Polly Matzinger (62, 223), DAMPs trigger the activation of antigen-presenting cells, act as chemokines that recruit dendritic cells, macrophages, or T cells to the site of injury, or prime immune cells, i.e., they contribute to trained immunity (5860, 62, 224226)

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While the prevalence of sporadic CAA increases with age, instances of early-onset CAA have been reported particularly in the context of prior neurosurgical interventions

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Peer review Peer review information Nature Reviews Neurology thanks Mu-Hong Chen, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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