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4 A decade of progress: novel antifungal drugs targeting resistance The main mechanism of antifungal action lies in inhibiting essential molecules, such as ergosterol (azole class) or 1,3--D-glucan (echinocandins), or by binding to ergosterol (polyene class), leading to the formation of pores and altering the integrity and permeability of the cell membrane, thereby affecting the membrane or fungal cell wall

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Altered protein folding and degradation Proteostasis mechanisms and redox-sensitive chaperones play a critical role in maintaining protein homeostasis within sperm cells [32]

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