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ROS formed as a natural byproduct of the normal metabolism of oxygen have important roles in cell signaling and homeostasis

DHODH/CoQH 2 system DHODH is located on the inner mitochondrial membrane and its primary function is to catalyze the synthesis of pyrimidine nucleotides

These differences probably account for remyelination occurring later in the cortex than in the CC: after acute cuprizone-induced demyelination, OPC repopulation and differentiation is much faster in the CC than in the cortex, resulting in later, incomplete remyelination in the cortex (Gudi et al., 2009

For instance, while quercetin has been reported to activate both enzymes, curcumin has shown potential as an activator of SIRT1, promoting its deacetylase activity and contributing to anti-inflammatory effects 178