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The complex pathophysiology and heterogeneity of the disease raises the speculation that combined treatment will be required for many patients

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The authors consider this phenomenon as a green biosynthesis of nanoparticles , and biological techniques that exploit plant cells and micro-organisms and for the biological production of metal sulphide nanoparticles are currently evaluated as an economically competitive and environmentally benign alternative to chemical processes [169,170,171,172,173]