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[,] Owing to acute liver failure, chronic hepatitis, or cirrhosis, the clearance of ammonia by the liver is diminished, they may reach to the brain, the elevated levels of ammonia and an inflammatory response work in synergy to cause astrocytes to swell and fluid to accumulate in the brain (cerebral edema), thus, affect cerebral function [,] [Figure 7]

Evidence suggest that Early depletions in nigral GSH levels may be directly lead to mitochondrial complex I activity inhibition and subsequent mitochondrial dysfunction which ultimately induces dopaminergic cell death related to PD

10.3390/cancers12082197 7 ChoiC

Matsumoto T, et al