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Yet, plasma concentrations of vitamin C 50 mol/L are sufficient to saturate muscle tissue vitamin C

Evidence consistent with intravascular phagocyte activation in meta-inflammation and T2DM includes leukocyte adhesion to the endothelium and formation of neutrophil extracellular traps (NETs), which can promote thrombophilia and directly injure endothelial cells [984,985,986,987,988]

Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS et al (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis

A key priority will be identifying novel regulatory nodes, particularly in understudied cellular compartments and tissues