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doi: 10.1111/j.1572-0241.2003.07385.x

Some research suggests that high-dose oral B12 supplements work just as well as B12 shots for raising B12 levels in people with a deficiency

Journal of Thoracic and Cardiovascular Surgery 170(4):1179-1184, 2025

This effect is notably reduced in adipocytes from obese individuals, suggesting that impaired cGMP signaling may contribute to the insulin resistance observed in T2DM