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From the gastrointestinal tract, these may include abdominal pain, diarrhea, constipation, nausea, or vomiting, which significantly limit the patients ability to function daily (Figure 1)

These observations have been translated into therapeutic approaches using iron oxide nanoparticles, which substantially increase intracellular labile iron pools and amplify radiation-induced lipid peroxidation by 3.2-fold [165]

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