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The disease is characterized by severe gastrointestinal dysmotility, sensorimotor peripheral neuropathy, severe muscle weakness, and progressive leukoencephalopathy, with patients usually dying from a combination of nutritional failure and muscular disability

Interestingly, glutamate also exert important modulatory effects on EECs, sending sensory signals to the vagus nerve [173] GABA is biosynthesized from glutamate due to the action of the enzyme glutamate decarboxylase, which is found in eukaryotic cells and in a broad spectrum of bacterial species [174]

142 GutteridgeI

One-dimensional 1 H CPMG (Carr-Purcell-Meiboom-Gill) NMR spectra were acquired from patients sera ( Fig