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A study in Clinical Therapeutics found that the absorption rate of oral B12 can be significantly lower than that of injections, particularly in older adults or those with digestive disorders

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In such a study (16-week randomized, double-blind, placebo-controlled), 204 individuals with obesity but not diabetes were treated with self-administered subcutaneous injections of pramlintide (nonforced dose escalation 240 g) or placebo three times a day, 15 minutes before meals without concomitant lifestyle intervention (200)

van Heijst (formerly Director, Dutch National Poison Control Centre, Utrecht, the Netherlands) on the clinical aspects of cyanide antidotes