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Impaired glucose metabolism Neurons primarily rely on glucose for energy production via oxidative phosphorylation (OXPHOS) in healthy brains

Parkinsons disease Parkinsons disease (PD), the most common neurodegenerative movement disorder, is characterized by accelerated neuronal death of primarily dopaminergic neurons and the accumulation of -synuclein 200

Most disease-causing mutations in these proteins occur in low-complexity domains mediating liquid-liquid phase separation to alter protein conformation, which promotes the aggregation and disrupts RNA regulation while also generating additional toxicity

Therefore, reduction of IL-6 and inflammatory cell accumulation may inhibit glycocalyx degradation during acute pancreatitis and protect the endothelium