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In vitro human systems, organ-on-chip, in silico and PBPK models, omics-based assays

Clinical Features Polyuria, polydipsia, polyphagia, and weight loss Nausea, vomiting, abdominal pain Dry mouth, sunken eyes, tachycardia, hypotension, Deep, rapid breathing (Kussmaul respiration) to compensate for acidosis Characteristic fruity (acetone) odor on breath Drowsiness, confusion, and in severe cases, coma E

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