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Thus, the RsrA regulatory circuit provides another example, comparable to OxyR, in which the modification of a regulatory protein thiol group can be linked to a change in the transcriptional output of genes that remediate stress

Psychiatry 34 LeeM.ChoT.JantaratnotaiN.WangY

Given the functional interdependencies between the molecular metabolites in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that links tissue and organ systems

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