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Description

Using non-targeted metabolomics and RNA sequencing, this study investigates the mechanisms underlying hypertension-induced ED

Acceleration of cleavage of the carbon-cobalt bond of sterically hindered alkylcobalamins by binding to apoprotein of diol dehydrase

It is initiated by changes in intracellular and extracellular lipid peroxidation levels, the balance in GSH oxidation and reduction, and intracellular iron metabolism abnormalities, which promote CNS damage and neuronal death [130]