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Microdose-Specific Considerations Lower starting dose may reduce the severity or frequency of GI side effects during initiation All boxed warnings and contraindications still apply regardless of dose Your provider will titrate the dose upward based on tolerance and response References Tirzepatide ODT Pills (Compounded) Tirzepatide Oral Dissolving Tablets (ODT) provide a needle-free oral form of the same dual GIP/GLP-1 receptor agonist as injectable tirzepatide

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RNA sequencing Total RNA was extracted from adipose tissue using the QIAzol Lysis Reagent (#79306, Qiagen Venlo, Netherlands) and from liver using the Nucleospin RNA kit (#740955, Macherey-Nagel GmbH & Co, Dren, Germany)