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Each mechanism of dysfunction at the pre-synaptic, post-synaptic, and peri-synaptic level offers itself as a target for intervention to improve stabilization, junctional signaling, and synapse integrity [213], potentially even before symptomatic weakness in those with genetic susceptibilities

This naturally occurring peptide with numerous physiological benefits has been synthesized enzymatically under in vitro conditions

The incorporation of these technologies is likely to improve cardiovascular medicine and accelerate the change from molecular mechanisms to clinical practice, ultimately realizing the 4P vision of precision medicine: Predictive, Preventive, Personalized, and Participatory

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