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FIGURE 10 Notably, activators of SIRT1, such as metformin, have demonstrated the ability to inhibit Th17 cell differentiation and downregulate IL-17A and RORt levels by promoting STAT3 deacetylation ( In summary, our study primarily investigated the beneficial effects of GHK-Cu in UC, using a DSS-induced colitis mouse model and an in vitro co-culture system, suggesting that GHK-Cu may exert anti-inflammatory properties and its role in facilitating the repair of UC by regulating SIRT1/STAT3 signaling pathway

Although the current work extends previous MWM studies by focusing on search strategies next to escape latencies, it has to be noted, that the Pathfinder analysis only indicates which search strategy is predominantly used but fails to notice transitions between different strategies within a single trial

All testing was done during the light period and mice were habituated to the testing room for 1 h prior to experimentation