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Alternatively, consider non-peptide weight loss medications or bariatric surgery for individuals with severe obesity unresponsive to pharmacotherapy

injections of 200 nmol kg 1 MK-801 (n = 8 mice and n = 4 cages), 600 nmol kg 1 MK-801 (n = 7 mice and n = 4 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 7 days

All data acquisitions were performed on a Titan Krios (Thermo Fisher Scientific) with a K3 camera (Gatan) at a magnification of 105,000, corresponding to a super-resolution pixel size of 0.4125 (or a nominal pixel size of 0.825 after binning by 2)

Tocotrienols are prominently present in the seed endosperm of most monocots, fruits of dicotyledonous plants, and the latex of rubber trees (Horvath et al., 2006, Zeng et al., 2024)