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Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, et al

No Human Adverse-Event Programme Without a controlled clinical development programme, the frequency and severity of possible adverse reactions cannot be estimated reliably

Given that both MitoQ and DPI target mitochondrial function, we used the Loewe synergy model, which is particularly suited for evaluating the combined effects of drugs with similar mechanisms of action (36)