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Methods: Suicide gene-meditated ablation of p16Ink4a-expressing senescent cells was carried out through intraperitoneal injection of AP20187 into young (8-week-old) or aging(20-month-old) INK-ATTAC mice at or age respectively

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This highlights the significance of the peroxisome-ether-phospholipid axis in influencing the susceptibility of cells to ferroptosis, underscores the distinctive functional lipid class of PUFA-ePLs that undergoes dynamic regulation during cellular state transitions, and implies the existence of multiple regulatory nodes that can be targeted for therapeutic intervention in ovarian cancer

At this point, the patient indicated a pain intensity of 5-6 on the VAS