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Initial work by Carter and colleagues [448] where they demonstrated an increase in time to exhaustion performance while cycling after rinsing (but not swallowing) the oral cavity with a carbohydrate solution versus a no carbohydrate rinse revealed that receptors in the brain might be linked to the mere presence of carbohydrate in the mouth, which subsequently can work to improve various types of exercise performance

Glutamate can then undergo further metabolism to produce important intermediates like -ketoglutarate (-KG), which is a key substrate in the TCA cycle for ATP production and anaplerosis

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Calabrese et al., 2021)