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Therefore, roles and mechanism of catecholamine excess for the pathogenesis of TTC have been extensively investigated, mainly focused on adrenergic stimulation and -adrenoceptor signaling

Although the most commonly reported adverse events were gastrointestinal side effects such as nausea, vomiting, and diarrhoea, the treatment was well tolerated in the study population [59, 60]

Its small molecular weight (~505 Da) and lipophilic character support oral capsule administration consistent with the published research literature

Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats